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Lookup NU author(s): Adnan Rafiq,
Emeritus Professor Bernard Golding
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The supernucleophilic cobalt compound, cob(I)alamin, has been kinetically characterized with respect to its ability to bring about transalkylation of adducts to DNA phosphates (phosphotriesters). The reactivity of cob(I)alamin toward different phosphotriesters (model compounds and methylated DNA), as well as its specificity toward DNA-phosphate adducts, has been investigated. Through nucleophilic displacement on the alkyl by cob(I)alamin, the alkyl groups (methyl and ethyl) were transferred from phosphotriesters within minutes at room temperature. In contrast, methylated nucleosides (base adducts) were stable in the presence of cob(I)alamin.
Author(s): Haglund J, Rafiq A, Ehrenberg L, Golding BT, Tornqvist M
Publication type: Article
Publication status: Published
Journal: Chemical Research in Toxicology
ISSN (print): 0893-228X
ISSN (electronic): 1520-5010
Publisher: American Chemical Society
PubMed id: 10775324
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