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Comparative trends in cause-specific fetal and neonatal mortality in twin and singleton births in the North of England, 1982-1994

Lookup NU author(s): Dr Svetlana Glinianaia, Dr Stephen Sturgiss


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Objective. To examine trends in cause- and birthweight-specific fetal and neonatal mortality rates in twins and singletons. Design. Descriptive analysis based on a regional register. Setting. The Northern Health Region of England, 1982-1994. Sample. Two hundred and thirty-six fetal and 356 neonatal twin deaths; 2687 fetal and 2301 neonatal singleton deaths from a population of 10,734 twins and 505,477 singletons. Main outcome measures. Fetal and neonatal autopsy rates, cause- and birthweight-specific fetal and neonatal mortality rates in twins and singletons. Results. The extended perinatal mortality (including stillbirths and neonatal deaths) rate (EPMR) was 55.2 per 1000 in 1982-1994 in twins compared with 9.9 per 1000 in singletons. The relative risk for twin compared with singleton deaths was 5.6 (95% CI 5.1-6.1) being highest for immaturity (12.9, 95% CI 11.1-15.0). A significant decrease in the EPMR occurred in both twins and singletons in 1988-1994 compared with 1982-1987. The EPMR decreased mainly due to a reduction of deaths from antepartum asphyxia in twins and intrapartum asphyxia and trauma in singletons, as well as a reduction in congenital malformations in both groups. In both twins and singletons, birthweight-specific mortality rates improved between 1982-1987 and 1988-1994. Conclusion. The higher relative risk for twin deaths remained stable due to a similar decrease in the EPMR for both twins and singletons. The cause-specific relative risk in twins declined for antepartum asphyxia. The mortality rate resulting from lethal congenital malformations decreased in twins and singletons mainly due to earlier detection and subsequent termination of pregnancy.

Publication metadata

Author(s): Sturgiss SN; Glinianaia SV; Pharoah P

Publication type: Article

Publication status: Published

Journal: British Journal of Obstetrics and Gynaecology

Year: 2000

Volume: 107

Issue: 4

Pages: 452-460

ISSN (print): 0306-5456

ISSN (electronic): 1471-0528

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1471-0528.2000.tb13261.x

PubMed id: 10759261


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