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One year follow-up of parkinsonism in dementia with Lewy bodies

Lookup NU author(s): Dr Clive Ballard, Professor John O'Brien, Dr Alan Swann, Dr David Neill, Professor David Burn, Emeritus Professor Robert Perry, Professor Ian McKeith


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The progression of parkinsonism over 1 year was evaluated in a prospective cohort of patients (n = 338), suffering from dementia with Lewy bodies (DLB), Alzheimer's disease (AD) or vascular dementia (VaD). Parkinsonism was assessed using the modified Unified Parkinson's Disease Rating Scale. Significant parkinsonism was significantly commoner in DLB sufferers (71%) than amongst patients with AD (7%) or VaD (10%). DLB patients with established parkinsonism had an annual increase in severity of 9%, but progression was more rapid (49% in 1 year) in patients with early parkinsonism. Parkinsonism was frequent at all severities in DLB patients, but usually only present in other dementias when MMSE<10. (C) 2000 S. Karger AG, Basel.

Publication metadata

Author(s): McKeith I; Perry R; O'Brien J; Burn D; Ballard C; Swann A; Neill D; Lantos P; Holmes C; Ince P

Publication type: Article

Publication status: Published

Journal: Dementia and Geriatric Cognitive Disorders

Year: 2000

Volume: 11

Issue: 4

Pages: 219-222

Print publication date: 01/01/2000

ISSN (print): 1420-8008

ISSN (electronic): 1421-9824

Publisher: S Karger AG


DOI: 10.1159/000017240

PubMed id: 10867448


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