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Expression of cyclin-dependent kinase inhibitor p21((WAF1)) and p53 tumour suppressor gene in laryngeal cancer

Lookup NU author(s): Professor John LunecORCiD, Vanessa Ashton, Jennifer Wilson


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The prognostic value of the expression of the cyclin-dependent kinase inhibitor p21 and the p53 tumour suppressor gene was examined using immunohistochemistry in 60 patients with laryngeal cancer. Multivariate analysis using Cox's proportional hazard method, showed that p21 expression (P = 0.02) and advanced T stage (P = 0.003) significantly predicted survival. It was concluded that p21 expression may be a useful prognostic indicator in laryngeal cancer.

Publication metadata

Author(s): Jeannon, J., Soames, J, Lunec, J, Awwad, S., Ashton, V., Wilson, J.

Publication type: Article

Publication status: Published

Journal: Clinical Otolaryngology and Allied Sciences

Year: 2000

Volume: 25

Issue: 1

Pages: 23-27

Print publication date: 01/01/2000

ISSN (print): 0307-7772

ISSN (electronic): 1749-4486


DOI: 10.1046/j.1365-2273.2000.00318.x

PubMed id: 10764233


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