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Distribution of amyloid β42 in relation to the cerebral microvasculature in an elderly cohort with Alzheimer's disease

Lookup NU author(s): Professor Alan ThomasORCiD, Dr Christopher Morris, Emeritus Professor Nicol Ferrier, Professor Raj KalariaORCiD


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Amyloid β (Aβ) deposits and neurofibrillary pathology are characteristic features of Alzheimer's disease (AD). The association of Aβ with cerebral vessels is an intriguing feature of AD. While some degree of cerebral Aβ angiopathy involving the leptomeninges and intraparenchymal vessels occurs in almost all cases of AD, the proportion of microvessels within a neocortical region containing deposits of Aβ peptide is not known. In this study, we examined a cohort of clinically and pathologically evaluated AD cases to assess the percentage of cerebral microvessels in the temporal cortex and parahippocampal gyrus associated with the predominant, Aβ42 form of the peptide. We also assessed whether the distribution and burden of amyloid was related to apolipoprotein E (APOE) genotype. Using double immunostaining methods, we surprisingly found that at least 40% of the microvessels in the two brain regions contained Aβ42 deposits. There was no correlation of such localization with APOE genotype, however, ε4 homozygotes revealed a greater burden of Aβ40. These observations suggest that high proportions of cortical microvessels are associated with Aβ42, which may affect microvascular function.

Publication metadata

Author(s): Kalaria RN; Morris CM; Ferrier IN; Thomas AJ

Publication type: Article

Publication status: Published

Journal: Annals of the New York Academy of Sciences

Year: 2000

Volume: 903

Pages: 83-88

ISSN (print): 0077-8923

ISSN (electronic): 1749-6632

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1749-6632.2000.tb06353.x

PubMed id: 10818492


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