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A double-blind, placebo-controlled study of the tolerability and efficacy of a new kappa-opioid receptor agonist (R-84760) in patients with pain after dental surgery

Lookup NU author(s): Emeritus Professor Robin Seymour, Undrell Moore, John Hawkesford


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Objective: To determine the efficacy of a new kappa-opioid receptor agonist (R-84760) in patients with pain after third molar removal. Design: Randomised, double-blind, placebo-controlled study evaluating a single subcutaneous dose of R-84760 7μg. Setting: Day-stay oral surgery unit. Patients: 72 adult patients who had undergone removal of their impacted third molars under general anaesthesia. Main Outcome Measures: Pain intensity was assessed on a serial visual analogue scale (VAS) over a 4-hour investigation period. Patients had access to escape analgesics, and when these were taken, the time and dosage were recorded. Results: For all efficacy variables, R-84760 did not differ significantly from placebo (p > 0.05). Nearly all the patients required escape analgesics during the investigation period. Conclusions: R-84760, a kappa agonist, did not show efficacy in the management of postoperative pain after third molar surgery. The finding further highlights the equivocal efficacy of opioids in this pain model.

Publication metadata

Author(s): Hawkesford JE; Seymour RA; Moore U; Stassen L; Oshima T; Suggi M; Nimmo WS

Publication type: Article

Publication status: Published

Journal: Clinical Drug Investigation

Year: 2000

Volume: 20

Issue: 6

Pages: 409-414

ISSN (print): 1173-2563

ISSN (electronic): 1179-1918

Publisher: Adis International Ltd.


DOI: 10.2165/00044011-200020060-00003


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