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Lookup NU author(s): Emeritus Professor Robin Seymour,
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Objective: To determine the efficacy of a new kappa-opioid receptor agonist (R-84760) in patients with pain after third molar removal. Design: Randomised, double-blind, placebo-controlled study evaluating a single subcutaneous dose of R-84760 7μg. Setting: Day-stay oral surgery unit. Patients: 72 adult patients who had undergone removal of their impacted third molars under general anaesthesia. Main Outcome Measures: Pain intensity was assessed on a serial visual analogue scale (VAS) over a 4-hour investigation period. Patients had access to escape analgesics, and when these were taken, the time and dosage were recorded. Results: For all efficacy variables, R-84760 did not differ significantly from placebo (p > 0.05). Nearly all the patients required escape analgesics during the investigation period. Conclusions: R-84760, a kappa agonist, did not show efficacy in the management of postoperative pain after third molar surgery. The finding further highlights the equivocal efficacy of opioids in this pain model.
Author(s): Hawkesford JE; Seymour RA; Moore U; Stassen L; Oshima T; Suggi M; Nimmo WS
Publication type: Article
Publication status: Published
Journal: Clinical Drug Investigation
ISSN (print): 1173-2563
ISSN (electronic): 1179-1918
Publisher: Adis International Ltd.
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