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Synthesis and cross-coupling reactions of solid-supported alkylzinc reagents

Lookup NU author(s): Professor Richard Jackson, Leslie Oates

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Abstract

Hydroboration of Wang-supported pent-4-enoic acid 1, followed by transmetallation with Et2Zn, gives a solid-supported zinc reagent, 2, which undergoes palladium-catalysed coupling with aryl iodides, to give the corresponding 5-arylpentanoic acids 3 in moderate to good yields, after cleavage from the resin using TFA.

Publication metadata

Author(s): Jackson RFW, Oates LJ, Block MH

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2000

Issue: 15

Pages: 1401-1402

ISSN (print): 1359-7345

ISSN (electronic): 1364-548X

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/b003879m

DOI: 10.1039/b003879m

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