Toggle Main Menu Toggle Search

Open Access padlockePrints

Future therapeutic targets in mood disorders: the glucocorticoid receptor

Lookup NU author(s): Professor Richard McQuade, Professor Allan Young


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background. The hypercortisolaemia and dysfunction of the hypothalamic pituitary - adrenal (HPA) axis associated with mood disorders have been attributed to a breakdown in the glucocorticoid-receptor-mediated negative feedback mechanism regulating HPA activity. Reinstating normal feedback may be therapeutic in mood disorders. Aims. To review the evidence for the involvement of the glucocorticoid receptor in the pathogenesis and treatment of mood disorders. Method. Medline and hand searches were carried out, selecting literature relevant to psychiatrists and psychopharmacologists. Results. A dysfunction in glucocorticoid receptors is integral to the HPA abnormalities of mood disorders. Antidepressant and mood-stabilising drugs can up-regulate glucocorticoid receptors, restoring glucocorticoid function. Preliminary clinical studies targeting the glucocorticoid receptor are encouraging. Conclusions. Drugs designed specifically to up-regulate glucocorticoid receptors may be integral to future strategies in treating mood disorders. Declaration of interest. None.

Publication metadata

Author(s): Young AH; McQuade R

Publication type: Review

Publication status: Published

Journal: British Journal of Psychiatry

Year: 2000

Volume: 177

Pages: 390-395

Print publication date: 01/01/2000

ISSN (print): 0007-1250

ISSN (electronic): 1472-1465


DOI: 10.1192/bjp.177.5.390

PubMed id: 11059990