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Mitochondria and ageing

Lookup NU author(s): Dr David Cottrell, Emeritus Professor Doug Turnbull

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Abstract

Mitochondria have long been proposed as a perpetrator of aging. We review here the accumulating evidence for chronological alterations in the mitochondrion and discuss how these changes may cause cellular dysfunction and death. We conclude that although the evidence for aging changes in the level of oxidative stress, DNA mutations and biochemical deficiencies in mitochondria are convincing, there is little experimental evidence to link these changes directly with the cellular pathology of aging. Promising avenues for addressing this problem include the investigation of established mitochondrial DNA disorders and the development of animal models with mitochondrial defects. (C) 2000 Lippincott Williams and Wilkins.

Publication metadata

Author(s): Cottrell DA, Turnbull DM

Publication type: Review

Publication status: Published

Journal: Current Opinion in Clinical Nutrition and Metabolic Care

Year: 2000

Volume: 3

Issue: 6

Pages: 473-478

ISSN (print): 1363-1950

ISSN (electronic): 1473-6519

URL: http://dx.doi.org/10.1097/00075197-200011000-00009

DOI: 10.1097/00075197-200011000-00009

PubMed id: 11085833

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