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The successful use of fentanyl/fluanisone ('Hypnorm') as an anaesthetic for intracranial surgery in neonatal rats

Lookup NU author(s): Dr Gavin ClowryORCiD, Emeritus Professor Paul FlecknellORCiD


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This study reports on the successful use of fentanyl citrate and fluanisone ('Hypnorm') anaesthesia for intracranial surgery in neonatal (7-day-old) rats. Provided the anaesthetic was administered subcutaneously, the animals showed a very high survival rate in the short term (81/85, 95%) and showed no ill effects in the long term. The depth of anaesthesia was sufficient to allow the operation to be carried out without the animal reacting to any painful stimuli. However, the animals did make random movements during the period of surgical anaesthesia which were not related to any painful stimuli. Although these movements did not interfere with the surgery performed here, such movements would interfere with operations requiring greater precision, such as the localized micro-injection of neural tracers.

Publication metadata

Author(s): Clowry GJ, Flecknell PA

Publication type: Article

Publication status: Published

Journal: Laboratory Animals

Year: 2000

Volume: 34

Issue: 3

Pages: 260-264

Print publication date: 01/01/2000

ISSN (print): 0023-6772

ISSN (electronic): 1758-1117

Publisher: Royal Society of Medicine Press Ltd


DOI: 10.1258/002367700780384771

PubMed id: 11037119


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