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Resistance-modifying agents. Part 7: 2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of α1-acid glycoprotein (AGP)

Lookup NU author(s): Hannah Barlow, Professor Nicola CurtinORCiD, Professor Alan Calvert, Emeritus Professor Bernard Golding, Professor Herbie Newell, Peter Smith, Professor Roger Griffin

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Abstract

The synthesis and biological evaluation of potent 4,8-dibenzylaminopyrimidopyrimidine nucleoside transport inhibitors, with reduced binding to α1-acid glycoprotein, is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

Publication metadata

Author(s): Barlow, H. C., Bowman, K. J., Curtin, N. J., Calvert, A. H., Golding, B. T., Huang, B., Loughlin, P. J., Newell, D. R., Smith, P. G., Griffin, R. J.

Publication type: Article

Publication status: Published

Journal: Bioorganic and Medicinal Chemistry Letters

Year: 2000

Volume: 10

Issue: 6

Pages: 585-589

Print publication date: 20/03/2000

ISSN (print): 0960-894X

ISSN (electronic): 1464-3405

URL: http://dx.doi.org/10.1016/S0960-894X(00)00053-6

DOI: 10.1016/S0960-894X(00)00053-6

PubMed id: 10741559

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