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Serum S-100β protein is a potential biochemical marker for cerebral oedema complicating severe diabetic ketoacidosis

Lookup NU author(s): Dr Elizabeth McIntyre, Dr Petros Perros


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Case report A 39-year-old man with Type 1 diabetes mellitus was hospitalized with severe diabetic ketoacidosis (DKA). Sixteen hours after admission he suddenly deteriorated having a respiratory then cardiac arrest. A brain computed tomography scan performed 2 h after the respiratory arrest showed severe cerebral oedema. Serial serum samples were stored and analysed for S-100β protein. The S- 100β protein concentration was initially normal (0.12 μg/l) then rose significantly before the onset of the respiratory arrest (8.5 h = 0.61 μg/l, 14.5 h = 0.9 μg/l, 18 h = 1.6 μg/l, 25.5 h = 3.1 μg/l, 34 h = 4.6 μg/l and 44 h = 19.5 μg/l). Conclusions: In this case of DKA, serum S-100β concentration rose coinciding with the onset of cerebral oedema, before it became clinically evident. Monitoring serum S-100β may have a useful role in the management of DKA.

Publication metadata

Author(s): McIntyre EA, Abraha HD, Perros P, Sherwood RA

Publication type: Article

Publication status: Published

Journal: Diabetic Medicine

Year: 2000

Volume: 17

Issue: 11

Pages: 807-809

ISSN (print): 0742-3071

ISSN (electronic): 1464-5491

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1046/j.1464-5491.2000.00370.x

PubMed id: 11131106


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