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A prospective randomised controlled study of patient-controlled propofol sedation in phobic dental patients

Lookup NU author(s): Professor Nick Girdler, John Lyne


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The safety and effectiveness of patient-controlled propofol sedation was prospectively assessed in 18 healthy, phobic dental patients. Using a randomised, crossover design each patient received two sessions of equivalent dental treatment under patient-controlled or clinician-controlled propofol sedation. The patient-controlled technique used 29.8% less drug (time-weighted dose) than the clinician-controlled method (p = 0.011). There was a high correlation between number of demands and number of doses actually infused during the patient-controlled technique (r = 0.99, p < 0.001). Clinically, the level of sedation was lighter and the degree of operator satisfaction was higher with patient-controlled sedation. Blood pressure and arterial oxygen saturation showed minimal changes and remained within normal ranges during both techniques. Patient-controlled sedation produced a greater reduction in dental and general anxiety compared with clinician-controlled sedation, but the difference did not reach statistical significance. Three times the number of patients expressed a preference for the patient-controlled, compared with the clinician-controlled, technique. Patient-controlled sedation provides safe and acceptable intra-operative anxiolysis for phobic dental patients, but with reduced propofol dosage.

Publication metadata

Author(s): Girdler NM; Lyne JP; Rynn D; Wilson KE

Publication type: Article

Publication status: Published

Journal: Anaesthesia

Year: 2000

Volume: 55

Issue: 4

Pages: 327-333

ISSN (print): 0003-2409

ISSN (electronic): 1365-2044

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1046/j.1365-2044.2000.01279.x

PubMed id: 10781117


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