Toggle Main Menu Toggle Search

Open Access padlockePrints

Early results of a non-heartbeating donor (NHBD) programme with machine perfusion

Lookup NU author(s): Basav Sen, Professor Derek Manas


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Freeman Hospital, Newcastle upon Tyne restarted their non-heartbeating donor (NHBD) programme in September 1998 using machine perfusion, due to early poor results with conventional cold storage (45% graft survival, phase II). Since then, 15 NHBD kidneys have been transplanted. The retrieval protocol consisted of in situ perfusion with a double balloon triple lumen cannula in Maastricht category II male donors age range 13-59 years. Mean primary warm ischaemic time was 24.8 min (range 10-44). All kidneys were machine perfused through a locally developed perfusion system. The viability was assessed by serial measurements of total GST (maximum acceptable limit of 200 units/l) and intrarenal vascular resistance (IRVR) was recorded. Fifteen of the 22 kidneys (68.62%) were transplanted. Delayed graft function (DGF) was seen in ten recipients (66.6%), two kidneys had immediate function (IF), one organ was exported, two recipients died of unrelated causes and a further seven kidneys were discarded (two had high tGST, two were infected and three had poor flow characteristics). In phase III, a success rate of 91.7% was thus achieved, which was better than the phase II period (P = 0.027, Fisher 2-tail test). Machine perfusion has been successfully introduced in phase III to the Newcastle NHBD programme and facilitates viability assessment of NHBD kidneys. © Springer-Verlag 2000.

Publication metadata

Author(s): Balupuri S, Buckley P, Mohamad M, Chidambaram Y, Gerstenkorn C, Sen B, Kirby J, Manas DM, Talbot D

Publication type: Article

Publication status: Published

Journal: Transplant International

Year: 2000

Volume: 13

Issue: 1

Pages: S255-S258

ISSN (print): 0934-0874

ISSN (electronic): 1432-2277

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1432-2277.2000.tb02031.x

PubMed id: 11112007


Altmetrics provided by Altmetric