Toggle Main Menu Toggle Search

Open Access padlockePrints

Antipruritic action of thalidomide

Lookup NU author(s): Emeritus Professor Sam Shuster


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


The effect of thalidomide on itch was studied in 11 patients with chronic pruritus from psoriasis, eczema, nodular prurigo, senile pruritus and primary biliary cirrhosis. Itch, assessed subjectively by the patients on a 10 cm line and measured objectively as nocturnal scratch movement, was decreased by thalidomide 200 mg on the 2 nights it was given. There was no improvement in the underlying disorders and it is concluded that thalidomide is a primary antipruritic agent. The patients all became drowsy and it seems likely that, as with most other antipruritic agents, the antipruritic action of thalidomide results from a central depressant effect. The primary antipruritic effect of thalidomide should now be assessed therapeutically.

Publication metadata

Author(s): Martina Daly B, Shuster S

Publication type: Article

Publication status: Published

Journal: Acta Dermato-Venereologica

Year: 2000

Volume: 80

Issue: 1

Pages: 24-25

Print publication date: 01/01/2000

ISSN (print): 0001-5555

ISSN (electronic): 1651-2057

Publisher: Society for the Publication of Acta Dermoto-Venereologica


DOI: 10.1080/000155500750012450

PubMed id: 10721827


Altmetrics provided by Altmetric