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The efficacy of buffered ketoprofen in postoperative pain after third molar surgery

Lookup NU author(s): Emeritus Professor Robin Seymour, John Hawkesford, Undrell Moore

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Abstract

Objective: To evaluate in a randomised, double-blind, placebo-controlled trial, the efficacy (time to onset of meaningful pain relief) of single doses of buffered ketoprofen (12.5 mg) and ibuprofen (200 mg) in 180 patients with postoperative pain after third molar surgery. Methods: 180 adult patients who had undergone third molar surgery under general anaesthesia participated in this study. After dosing, patients recorded their time to meaningful pain relief, pain intensity on both visual analogue scales and verbal rating scales, pain relief and the need for additional analgesia. Pain recordings were made at fixed time points over a 6-h investigation period. Result: Buffered ketoprofen (12.5 mg) provided quicker meaningful pain relief than placebo (P = 0.023). For secondary efficacy measures (SPIDS4, SPIDS6, TOTPAR4, TOTPAR6), the buffered ketoprofen was significantly superior to both placebo (P < 0.001) and ibuprofen (200 mg) (P < 0.05). Similarly, the amount of time before taking an escape analgesic was significantly less in the placebo group than both the ibuprofen and buffered ketoprofen groups (P < 0.03). Conclusions: Buffered ketoprofen (12.5 mg) provides effective pain control in the early postoperative period after third molar surgery. This ketoprofen preparation was also superior to ibuprofen (200 mg) with respect to both reducing pain intensity and providing an earlier onset of pain relief.

Publication metadata

Author(s): Hawkesford JE; Seymour RA; Moore U; Watkinson H

Publication type: Article

Publication status: Published

Journal: European Journal of Clinical Pharmacology

Year: 2000

Volume: 55

Issue: 11-12

Pages: 801-806

Print publication date: 01/01/2000

ISSN (print): 0031-6970

ISSN (electronic): 1432-1041

Publisher: Springer

URL: http://dx.doi.org/10.1007/s002280050700

DOI: 10.1007/s002280050700

PubMed id: 10805057

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