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Kill and cure: Dietary augmentation of immune defences against colon cancer

Lookup NU author(s): Professor John Mathers


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At its most fundamental, cancer is a genetic disease resulting from inherited or acquired mutations in tumour suppressor genes and proto-oncogenes. Environmental factors, including ingested food components, interact with genetic inheritance to determine individual cancer risk. There is growing evidence that the immune system exerts selective pressure during neoplastic development. Tumour cells that evade this immunosurveillance because they are non-antigenic or because they defend themselves successfully against immune attack have a survival advantage. Effective chemopreventative agents will include dietary components that enhance the immune system's ability to identify transformed cells and to target them for apoptosis.

Publication metadata

Author(s): Mathers JC; Armstrong F

Publication type: Article

Publication status: Published

Journal: Proceedings of the Nutrition Society

Year: 2000

Volume: 59

Issue: 2

Pages: 215-220

ISSN (print): 0029-6651

ISSN (electronic): 1475-2719

Publisher: Cambridge University Press


DOI: 10.1017/S0029665100000240

PubMed id: 10946790


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