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Does the mitochondrial transcription-termination complex play an essential role in controlling differential transcription of mitochondrial DNA?

Lookup NU author(s): Simon Selwood, Professor Zofia Chrzanowska-LightowlersORCiD, Professor Robert Lightowlers


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The mechanism of mitochondrial transcription is well documented although the method of regulation remains obscure. The mitochondrial transcription-termination complex, mTERF, holds a key position in determining the fate of heavy-strand promotor-initiated transcripts and has been suggested as a candidate in the regulation of mitochondrial DNA (mtDNA) transcription. We report here the first example of a modulation of mTERF-complex binding activity concomitant with a differential mtDNA transcription rate. We suggest that these observations are indicative of a method of intra-organellar transcriptional fine tuning.

Publication metadata

Author(s): Selwood SP, Chrzanowska-Lightowlers ZMA, Lightowlers RN

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Colloquium on Organisms, Organs, Cells and Organelles - In Vivo and In Vitro Experimental Systems

Year of Conference: 2000

Pages: 154-159

ISSN: 0300-5127

Publisher: Biochemical Society Transactions, Portland Press

PubMed id: 10816118

Library holdings: Search Newcastle University Library for this item

ISBN: 14708752