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Lookup NU author(s): Sarah Jane Ross,
Professor Brian Morgan
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A genetic screen was performed in Saccharomyces cerevisiae to identify mechanisms important for the transcriptional activation of genes encoding antioxidant proteins. Thioredoxin peroxidase, Tsa1p, of the thioredoxin system, was found to be essential for the transcriptional induction of other components of the thioredoxin system, TRX2 (thioredoxin) and TRR1 (thioredoxin reductase), in response to H2O2. The expression of TRX2 and TRR1 is known to be regulated by the transcription factors Yap1p and Skn7p in response to H2O2, and the Tsa1p-dependent regulation of TRX2 requires the Yap1p/Skn7p pathway. The data suggest that expression of components of the thioredoxin system is dependent on the activity of Tsa1p in response to H2O2 in a Yap1p/Skn7p-dependent pathway.
Author(s): Ross SJ, Findlay VJ, Malakasi P, Morgan BA
Publication type: Article
Publication status: Published
Journal: Molecular Biology of the Cell
Print publication date: 01/01/2000
ISSN (print): 1059-1524
ISSN (electronic): 1939-4586
Publisher: American Society for Cell Biology
PubMed id: 10930459