Toggle Main Menu Toggle Search

Open Access padlockePrints

Effects of repeated anaesthesia with ketamine/medetomidine and of pre-anaesthetic administration of buprenorphine in rats

Lookup NU author(s): Dr Johnny RoughanORCiD, Emeritus Professor Paul FlecknellORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Two groups of rats were anaesthetized at weekly intervals for 6 weeks with either ketamine/medetomidine alone (60 mg/0.4 mg/kg i.p.) or ketamine/medetomidine (45 mg/0.3 mg/kg i.p.) one hour following buprenorphine (0.05 mg/kg s.c.). Animals that received buprenorphine had longer periods of surgical anaesthesia (P = 0.04) and a greater depression of both mean pedal withdrawal score (P < 0.01) and mean respiratory rate (P = 0.014). Mean total duration of anaesthesia was also greater in the buprenorphine group on day 1. Sleep times reduced with successive doses of anaesthetic in the buprenorphine group (P = 0.024). Two animals in the buprenorphine group died. Repeated anaesthesia with ketamine/medetomidine alone was not associated with anaesthetic mortality. These results indicate that although buprenorphine has a clear anaesthetic-sparing effect, its use with ketamine/medetomidine may be associated with an increased risk of anaesthetic-related mortality.

Publication metadata

Author(s): Roughan JV; Flecknell PA; Hedenqvist P

Publication type: Article

Publication status: Published

Journal: Laboratory Animals

Year: 2000

Volume: 34

Issue: 2

Pages: 207-211

ISSN (print): 0023-6772

ISSN (electronic): 1758-1117

Publisher: Royal Society of Medicine Press Ltd


DOI: 10.1258/002367700780457536

PubMed id: 10817461


Altmetrics provided by Altmetric