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Pd-catalysed C-C macrocyclisation of a simple tripeptide: Efficient total synthesis of K-13

Lookup NU author(s): Manuel Perez-Gonzalez, Professor Richard Jackson

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Abstract

The cyclic tripeptide K-13 has been prepared in 11 steps from commercially available starting materials (11% overall yield); the key step is the Pd-catalysed macrocyclisation of the zinc reagent prepared by selective insertion of zinc into the aliphatic C-I bond of the linear tripeptide 3, followed by Pd-catalysed macrocyclisation.

Publication metadata

Author(s): Perez-Gonzalez M, Jackson RFW

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2000

Issue: 24

Pages: 2423-2424

ISSN (print): 1359-7345

ISSN (electronic): 1364-548X

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/B008078K

DOI: 10.1039/B008078K

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