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Lookup NU author(s): Dr Suzy Leech,
Dr Niamh Leonard
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Aim - To investigate whether immunohistochemical staining for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) is useful in distinguishing Merkel cell carcinomas (MCCs) from metastatic small cell carcinomas (SCCs). Methods - Eleven cases of MCC and 10 of lung SCC were stained for CK20 and TTF-1. Results - Ten of 11 MCCs stained with the antibody to CK20. None was positive for TTF-1. No SCC stained with anti-CK20 and all stained strongly with anti-TTF-1. Conclusions - The use of both anti-CK20 and anti-TTF-1 can reliably distinguish between MCC and metastatic SCC, thus avoiding the need for a detailed clinical investigation of patients with MCC in whom metastatic SCC must be excluded.
Author(s): Leech SN; Leonard N; Kolar AJO; Barrett PD; Sinclair SA
Publication type: Article
Publication status: Published
Journal: Journal of Clinical Pathology
ISSN (print): 0021-9746
Publisher: BMJ Publishing Group
PubMed id: 11533085
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