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Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1

Lookup NU author(s): Dr Suzy Leech, Dr Niamh Leonard

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Abstract

Aim - To investigate whether immunohistochemical staining for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) is useful in distinguishing Merkel cell carcinomas (MCCs) from metastatic small cell carcinomas (SCCs). Methods - Eleven cases of MCC and 10 of lung SCC were stained for CK20 and TTF-1. Results - Ten of 11 MCCs stained with the antibody to CK20. None was positive for TTF-1. No SCC stained with anti-CK20 and all stained strongly with anti-TTF-1. Conclusions - The use of both anti-CK20 and anti-TTF-1 can reliably distinguish between MCC and metastatic SCC, thus avoiding the need for a detailed clinical investigation of patients with MCC in whom metastatic SCC must be excluded.

Publication metadata

Author(s): Leech SN; Leonard N; Kolar AJO; Barrett PD; Sinclair SA

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Pathology

Year: 2001

Volume: 54

Issue: 9

Pages: 727-729

ISSN (print): 0021-9746

ISSN (electronic):

Publisher: BMJ Publishing Group

URL: http://dx.doi.org/10.1136/jcp.54.9.727

DOI: 10.1136/jcp.54.9.727

PubMed id: 11533085

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