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The progression of cognitive impairment in dementia with Lewy bodies, vascular dementia and Alzheimer's disease

Lookup NU author(s): Dr Clive Ballard, Professor John O'Brien, Dr Christopher Morris, Dr Robert Barber, Dr Alan Swann, Dr David Neill, Professor Ian McKeith


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Background: Little is known about the rate of progression or associations of cognitive impairment in dementia with Lewy bodies (DLB), or the associations of accelerated decline. Method: Dementia patients from a case register were evaluated at baseline and 1 year follow-up using the Cambridge Assessment for Mental Disorders in the Elderly, section B (CAMCOG) and the Mini-Mental State Examination (MMSE) to determine the rate of cognitive decline. Operationalized clinical diagnoses were applied (NINCDS ADRDA for Alzheimer's disease (AD), NINCDS AIRENS for vascular dementia (VaD) and consensus criteria for DLB). Results: One hundred and ninety-three patients completed annual MMSE schedules (AD, 101; DLB, 64; VaD, 38), of whom 154 completed the CAMCOG. The magnitude of cognitive decline (MMSE, 4-5 points; CAMCOG, 12-14 points) was similar in each of the dementias. The strongest predictor of accelerated cognitive decline in DLB was the apolipoprotein E4 allele (17.5 vs 8.3 points decline on the CAMCOG). Conclusion: Over 1 year, DLB, VaD and AD patients had similar rates of cognitive decline overall. Apolipoprotein E4 may be an important predictor or more rapid decline in DLB. Copyright © 2001 John Wiley & Sons, Ltd.

Publication metadata

Author(s): McKeith I; Morris CM; O'Brien J; Barber R; Ballard C; Swann A; Neill D

Publication type: Article

Publication status: Published

Journal: International Journal of Geriatric Psychiatry

Year: 2001

Volume: 16

Issue: 5

Pages: 499-503

ISSN (print): 0885-6230

ISSN (electronic): 1099-1166

Publisher: John Wiley & Sons


DOI: 10.1002/gps.381

PubMed id: 11376466


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