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Expression of MUC1 and MUC2 glycoproteins in laryngeal cancer

Lookup NU author(s): Emerita Professor Janet Wilson

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Abstract

The aim of this study was to examine the expression of MUC1 and MUC2 glycoproteins in laryngeal cancer and to determine if mucin expression is related to prognosis. The study included laryngeal specimens from 57 patients comprising of 36 laryngeal carcinomas and 21 normal controls. High MUC1 expression was found in both carcinomas and normal control groups (P = 0.689, Fisher's exact test). High levels of MUC2 expression were only detected in carcinomas versus controls (P = 0.009, Fisher's exact test). Using multivariate analysis neither MUC1 nor MUC2 expression significantly related to survival. MUC1 expression however, did correlate with T stage. Advanced T stage was associated with prognosis (P = 0.001).


Publication metadata

Author(s): Wilson JA; Jeannon J-P; Aston V; Stafford FW; Soames JV

Publication type: Article

Publication status: Published

Journal: Clinical Otolaryngology and Allied Sciences

Year: 2001

Volume: 26

Issue: 2

Pages: 109-112

Print publication date: 01/01/2001

ISSN (print): 0307-7772

ISSN (electronic): 1365-2273

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1046/j.1365-2273.2001.00437.x

DOI: 10.1046/j.1365-2273.2001.00437.x

PubMed id: 11309050


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