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Random genetic drift determines the level of mutant mtDNA in human primary oocytes

Lookup NU author(s): Professor David Samuels, Dr Enid Michael, Emeritus Professor Doug Turnbull, Professor Patrick Chinnery


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We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes.

Publication metadata

Author(s): Brown DT, Samuels DC, Michael EM, Turnbull DM, Chinnery PF

Publication type: Article

Publication status: Published

Journal: American Journal of Human Genetics

Year: 2001

Volume: 68

Issue: 2

Pages: 533-536

Print publication date: 01/01/2001

ISSN (print): 0002-9297

ISSN (electronic): 1537-6605

Publisher: Cell Press


DOI: 10.1086/318190

PubMed id: 11133360


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