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Calcium and mitosis

Lookup NU author(s): Emeritus Professor Michael Whitaker, Mark Larman

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Abstract

Calcium is thought to be involved in regulating mitotic transitions. The basis for this view is set out. Recent data from experiments on sea urchin embryos is discussed. The relative simplicity of the embryonic cell cycle and the relative ease with which cell physiology can be done in sea urchin embryos has allowed the clear demonstration that the phosphoinositide-calcium-calmodulin signalling pathway is required for and regulates mitosis entry and anaphase onset. The relevance of the sea urchin work to mitosis in other cell types is briefly discussed. © 2001 Academic Press.

Publication metadata

Author(s): Whitaker M, Larman MG

Publication type: Review

Publication status: Published

Journal: Seminars in Cell and Developmental Biology

Year: 2001

Volume: 12

Issue: 1

Pages: 53-58

Print publication date: 01/01/2001

ISSN (print): 1084-9521

ISSN (electronic): 1096-3634

URL: http://dx.doi.org/10.1006/scdb.2000.0217

DOI: 10.1006/scdb.2000.0217

PubMed id: 11162747

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