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Lookup NU author(s): Professor David Elliott
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Human mitochondrial DNA polymerase, encoded by POLG, contains a polyglutamine tract encoded by a CAG microsatellite repeat1,2. Analysis of POLG genotypes in different populations identified an association between absence of the common, tenrepeat allele and male infertility typified by a range of sperm quality defects but excluding azoospermia.
Author(s): Elliott DJ; Rovio AT; McNay D; Harrison RF; Hughes B; Barrett T; Bailey DMD; Mehmet D; Jequier AM; Hargreave TB; Kao S-H; Cummins JM; Marchington DR; Barton DE; Cooke HJ; Wei Y-H; Wichmann L; Poulton J; Jacobs HT; Donat S; Schuppe H-C; Abel J; Fritsche E; Laippala P; Ahola AL
Publication type: Article
Publication status: Published
Journal: Nature Genetics
Print publication date: 01/01/2001
ISSN (print): 1061-4036
ISSN (electronic): 1546-1718
Publisher: Nature Publishing Group
PubMed id: 11687794
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