Browse by author
Lookup NU author(s): Dr Ann Clark,
Emeritus Professor Barry Hirst
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The specialised antigen sampling M cells represent an efficient portal for mucosal drug and vaccine delivery. Delivery may be achieved using synthetic particulate delivery vehicles including poly(DL-lactide-co-glycolide) microparticles and liposomes. M cell interaction of these delivery vehicles is highly variable, and is determined by the physical properties of both particles and M cells. Delivery may be enhanced by coating with reagents including appropriate lectins, microbial adhesins and immunoglobulins which selectively bind to M cell surfaces. Live attenuated microorganisms are also suitable as vaccines and mucosal vectors and many, including Salmonella typhimurium, innately target to M cells. After cell surface adhesion, delivery vehicles are rapidly transported across the M cell cytoplasm to underlying lymphoid cells and may subsequently disseminate via the lymphatics. Further definition of M cell development and function should permit exploitation of their high transcytotic capacity for safe and reliable mucosal delivery. © 2001 Elsevier Science B.V. All rights reserved.
Author(s): Hirst BH; Clark MA; Jepson MA
Publication type: Review
Publication status: Published
Journal: Advanced Drug Delivery Reviews
ISSN (print): 0169-409X
ISSN (electronic): 1872-8294
PubMed id: 11489335