Browse by author
Lookup NU author(s): Professor Alan Boddy, Dr Martin Highley, Dr John Fenwick, Professor Alan Calvert
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The frequent need to obtain an estimate of renal function in cancer patients, not least for targeting carboplatin dose, has led to a number of approaches to estimate glomerular filtration rate (GFR). This study aimed to develop a simple and reliable method to estimate GFR using readily-available patient characteristics. Data from 62 patients with estimates of 51Cr-EDTA clearance were analysed to determine the most appropriate formula relating this method of measuring GFR to patient characteristics. The population pharmacokinetics of 51Cr-EDTA were analysed using NONMEM to evaluate the influence of each covariate. The formulae derived were then validated using a further 38 patients and compared with those obtained using existing formulae. 51Cr-EDTA clearance (GFR) was positively related to Dubois surface area, negatively related to age, and inversely related to serum creatinine (SCr). Females had lower 51Cr-EDTA clearance than males. The enzymatic method of SCr assay gave more reliable results than the Jaffe colorimetric method. A measure of creatine kinase significantly improved the estimation of GFR. The new formula produced estimates of GFR which were less biased (Mean Prediction Error = -3%) and more precise (Mean Absolute Prediction Error = 12%) than Cockcroft and Gault (-8% and 16%) or Jelliffe (-15% and 19%) estimates. The formulae developed here can be used to provide reliable estimates of GFR, particularly in regard to targeted dosing of carboplatin. © 2001 Cancer Research Campaign.
Author(s): Wright, J., Boddy, A. V., Highley, M., Fenwick, J., McGill, A., Calvert, A. H.
Publication type: Article
Publication status: Published
Journal: British Journal of Cancer
Year: 2001
Volume: 84
Issue: 4
Pages: 452-459
Print publication date: 01/01/2001
ISSN (print): 0007-0920
ISSN (electronic): 1532-1827
URL: http://dx.doi.org/10.1054/bjoc.2000.1643
DOI: 10.1054/bjoc.2000.1643
PubMed id: 11207037
Altmetrics provided by Altmetric
