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Lookup NU author(s): Simon Selwood,
Professor Robert Lightowlers,
Professor Zofia Chrzanowska-Lightowlers
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Mammalian mitochondria are known to proliferate in response to several stimuli. Proliferation requires an increase in expression of genes encoding proteins involved in mitochondrial biogenesis, as well as in the replication and expression of mitochondrial DNA (mtDNA). In contrast, we report that inhibiting mitochondrial protein synthesis causes a modulation in mtDNA gene expression without the concomitant increase in proliferative markers. Further, inhibition results in the production of a previously unidentified light-strand mitochondrial RNA that spans the entire displacement loop, the function of which is currently unknown. © 2001 Federation of European Biochemical Societies.
Author(s): Selwood SP, McGregor A, Lightowlers RN, Chrzanowska-Lightowlers ZMA
Publication type: Article
Publication status: Published
Journal: FEBS Letters
ISSN (print): 0014-5793
ISSN (electronic): 1873-3468
PubMed id: 11311238
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