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Inhibition of mitochondrial protein synthesis promotes autonomous regulation of mtDNA expression and generation of a new mitochondrial RNA species

Lookup NU author(s): Simon Selwood, Anthony McGregor, Professor Robert Lightowlers, Professor Zofia Chrzanowska-LightowlersORCiD

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Abstract

Mammalian mitochondria are known to proliferate in response to several stimuli. Proliferation requires an increase in expression of genes encoding proteins involved in mitochondrial biogenesis, as well as in the replication and expression of mitochondrial DNA (mtDNA). In contrast, we report that inhibiting mitochondrial protein synthesis causes a modulation in mtDNA gene expression without the concomitant increase in proliferative markers. Further, inhibition results in the production of a previously unidentified light-strand mitochondrial RNA that spans the entire displacement loop, the function of which is currently unknown. © 2001 Federation of European Biochemical Societies.

Publication metadata

Author(s): Selwood SP, McGregor A, Lightowlers RN, Chrzanowska-Lightowlers ZMA

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 2001

Volume: 494

Issue: 3

Pages: 186-191

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/S0014-5793(01)02345-6

DOI: 10.1016/S0014-5793(01)02345-6

PubMed id: 11311238

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