Toggle Main Menu Toggle Search

Open Access padlockePrints

Temporal variations in plasma vitamin K and lipid concentrations and clotting factor activity in humans

Lookup NU author(s): Professor Farhad Kamali, Dr Hilary Wynne, Dr Patrick Kesteven

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

There is no information available on temporal variability in plasma vitamin K concentrations and its relationship to coagulation processes. We investigated the possible existence of temporal changes in plasma vitamin K and lipid concentrations and activity of clotting factors II, VII, IX, and X and relationships between these variables. Plasma vitamin K and lipid concentrations and clotting factor activity were measured at four-hour intervals for 28 hours in a group of healthy volunteers. Temporal variations existed in plasma vitamin K concentrations, with a mean maximum at 22:00 hr and a mean minimum (32% of the maximum) at 10:00 hr. Plasma triglycerol concentrations mirrored the changes in vitamin K concentrations. Mean factor VII activity was positively correlated with mean total plasma cholesterol concentrations (r = 0.714; P < 0.0001) and with mean plasma low density lipoprotein (LDL) cholesterol concentrations (r = 0.461; P < 0.0001). No distinct correlations were found between plasma vitamin K concentrations and either high density lipoprotein (HDL) or LDL cholesterol concentrations, or between triglycerol, HDL, or LDL cholesterol concentrations and functional activity of factors II, IX, and X. Plasma vitamin K concentrations did not correlate with the functional activity of any of the clotting factors. The presence of a correlation between plasma cholesterol concentrations and factor VII activity for blood samples collected at four-hour intervals suggests that plasma cholesterol concentrations may have a more acute effect on factor VII activity. Temporal variations in plasma vitamin K concentrations indicate that a single time point measurement may be an inappropriate method of establishing vitamin K status in an individual. © 2001 Wiley-Liss, Inc.


Publication metadata

Author(s): Kamali F; Kesteven P; Wynne HA; Edwards C; Wood P

Publication type: Article

Publication status: Published

Journal: American Journal of Hematology

Year: 2001

Volume: 68

Issue: 3

Pages: 159-163

ISSN (print): 0361-8609

ISSN (electronic): 1096-8652

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/ajh.1172

DOI: 10.1002/ajh.1172

PubMed id: 11754396


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share