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Temporal variations in plasma vitamin K and lipid concentrations and clotting factor activity in humans

Lookup NU author(s): Professor Farhad Kamali, Dr Hilary Wynne, Dr Patrick Kesteven


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There is no information available on temporal variability in plasma vitamin K concentrations and its relationship to coagulation processes. We investigated the possible existence of temporal changes in plasma vitamin K and lipid concentrations and activity of clotting factors II, VII, IX, and X and relationships between these variables. Plasma vitamin K and lipid concentrations and clotting factor activity were measured at four-hour intervals for 28 hours in a group of healthy volunteers. Temporal variations existed in plasma vitamin K concentrations, with a mean maximum at 22:00 hr and a mean minimum (32% of the maximum) at 10:00 hr. Plasma triglycerol concentrations mirrored the changes in vitamin K concentrations. Mean factor VII activity was positively correlated with mean total plasma cholesterol concentrations (r = 0.714; P < 0.0001) and with mean plasma low density lipoprotein (LDL) cholesterol concentrations (r = 0.461; P < 0.0001). No distinct correlations were found between plasma vitamin K concentrations and either high density lipoprotein (HDL) or LDL cholesterol concentrations, or between triglycerol, HDL, or LDL cholesterol concentrations and functional activity of factors II, IX, and X. Plasma vitamin K concentrations did not correlate with the functional activity of any of the clotting factors. The presence of a correlation between plasma cholesterol concentrations and factor VII activity for blood samples collected at four-hour intervals suggests that plasma cholesterol concentrations may have a more acute effect on factor VII activity. Temporal variations in plasma vitamin K concentrations indicate that a single time point measurement may be an inappropriate method of establishing vitamin K status in an individual. © 2001 Wiley-Liss, Inc.

Publication metadata

Author(s): Kamali F; Kesteven P; Wynne HA; Edwards C; Wood P

Publication type: Article

Publication status: Published

Journal: American Journal of Hematology

Year: 2001

Volume: 68

Issue: 3

Pages: 159-163

ISSN (print): 0361-8609

ISSN (electronic): 1096-8652

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/ajh.1172

PubMed id: 11754396


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