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Risk factors for the development of Clostridium difficile toxin-associated diarrhoea: A pilot study

Lookup NU author(s): Dr Salma Ayis, Professor Kate Gould


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This study was a pilot investigation of risk factors for the development of Clostridium difficile toxin-associated diarrhoea and in particular the differential influence of antimicrobial agents. The study was a retrospective case- control design conducted at Freeman Hospital, Newcastle upon Tyne. Cases were inpatients with stool positive C. difficile toxin diarrhoea and two controls were drawn for each case matched for age (+/-5 years) and type of admission (emergency or elective). Using conditional logistic regression analysis, cephalosporins and erythromycin were found to be statistically significantly associated with Clostridium difficile toxin associated-diarrhoea. The results form the basis for designing a larger, prospective study. Copyright © 2001 John Wiley & Sons, Ltd.

Publication metadata

Author(s): Aziz EE, Ayis S, Gould FK, Rawlins MD

Publication type: Article

Publication status: Published

Journal: Pharmacoepidemiology and Drug Safety

Year: 2001

Volume: 10

Issue: 4

Pages: 303-308

Print publication date: 01/06/2001

ISSN (print): 1053-8569

ISSN (electronic): 1099-1557

Publisher: John Wiley & Sons


DOI: 10.1002/pds.598

PubMed id: 11760491


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