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Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors: How many genetic subgroups are there?

Lookup NU author(s): Dr Maria Lastowska, Dr Nicholas Bown, Professor Andrew Pearson


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ProcedureAnalysis of comparative genomic hybridization (CGH) data of 120 tumors from four different studies, and data of 84 previously unpublished tumors, allowed delineation of at least six different genetic subsets of neuroblastomas.Results and ConclusionsA small number of tumors show no detectable imbalances. A second group of tumors presents with gains and losses of whole chromosomes and is found predominantly in prognostically favorable stage 1 and 2 tumors. The remaining groups are characterized by the presence of partial chromosome imbalances, and are found mostly in stage 3, 4, and 4S tumors. The third group shows 17q gain without 11q loss, 1p loss, or MYCN amplification (MNA). The fourth group has 1p deletion or MNA, and finally, a fifth group shows 11q loss without 1p deletion or MNA, and is found mainly in stage 4 tumors. The latter group is significantly associated with losses of 3p, 4p, and 14q.

Publication metadata

Author(s): Vandesompele J, Speleman F, Van Roy N, Laureys G, Brinkschmidt C, Christiansen H, Lampert F, Lastowska M, Bown N, Pearson A, Nicholson JC, Ross F, Combaret V, Delattre O, Feuerstein BG, Plantaz D

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 8th Advances in Neuroblastoma Research Conference (1998)

Year of Conference: 2001

Pages: 5-10

ISSN: 0098-1532

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/1096-911X(20010101)36:1<5::AID-MPO1003>3.0.CO;2-E

PubMed id:

Series Title: Medical and Pediatric Oncology

Series Editor(s): Andrew D.J. Pearson