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17q gain in neuroblastoma predicts adverse clinical outcome

Lookup NU author(s): Dr Nicholas Bown, Dr Seamus O'Neill


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Procedure. To establish the significance of chromosome 17 aberrations in the biology of neuroblastomas, the fresh-frozen material of 53 primary neuroblastomas (average patient age: 20.8 months; stage 1 or 2: n = 10; stage 3: n = 10; stage 4: n = 10; stage 4s: n = 23) was studied by means of comparative genomic hybridization (CGH). Follow-up data were available for 52 of 53 cases studied (average follow-up period: 26.4 months). Except for one, all cases had previously been analyzed for MYCN status (semiquantitative Southern blot analysis). Studies of LOH 1p36 (VNTR-PCR) had been performed on 28 of 53 cases. Results. Chromosome 17 gains were detected in 46 of 53 (86.8%) cases. Whole chromosome gains were mostly restricted to localized tumors (stage 1 or 2: 9 of 10 cases; stage 4s:19 of 23; stage 3: 2 of 10; stage 4:0 of 10 cases), whereas distal 17 gains were significantly associated with clinically advanced tumor stages and patients aged over 1 year at diagnosis. Univariate analyses revealed a statistically significant correlation of distal 17q gains with overall survival (P< 0.01, MYCN amplification: P < 0.01; 1p deletion: P < 0.01) and an elevated recurrency rate (17q: P = 0.02, MYCN amplification: P = 0.05; 1p deletion P = 0.3). There was a strong coincidence of distal 17q gains and 1p deletion or MYCN amplification (P < 0.01). Conclusion. Our data indicate that distal chromosome 17q gains are of major prognostic relevance for neuroblastoma patients. However, studies on a larger series of tumors have to be performed to assess whether or not these alterations are independent prognostic markers of a poor clinical outcome. © 2001 Wiley-Liss, Inc.

Publication metadata

Author(s): Bown N, Astowska M, Cotterill S, O'Neill S, Ellershaw C, Roberts P, Lewis I

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 8th Advances in Neuroblastoma Research Conference (1998)

Year of Conference: 2001

Pages: 14-19

ISSN: 0098-1532

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/1096-911X(20010101)36:1<14::AID-MPO1005>3.0.CO;2-G

Notes: Medical and Pediatric Oncology Special Issue: Advances in Neuroblastoma Research: 1998 Conference (Bath, UK, June 15-17 1998).

Series Title: Medical and Pediatric Oncology