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Lookup NU author(s): Dr Heather Bigg,
Emeritus Professor Drew Rowan
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The collagenases of the matrix metalloproteinase family are key enzymes in mediating irreversible cartilage collagen loss in arthritis. Inhibition of these enzymes is, therefore, an important therapeutic target. New approaches to collagenase inhibition include active site inhibitors designed for specific enzymes, inhibition of cell signalling molecules and transcription factors involved in collagenase gene expression, prevention of zymogen activation and induction of natural inhibitor production. © 2001 Elsevier Science Ltd.
Author(s): Rowan AD; Bigg HF
Publication type: Article
Publication status: Published
Journal: Current Opinion in Pharmacology
ISSN (print): 1471-4892
ISSN (electronic): 1471-4973
PubMed id: 11712757
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