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The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis

Lookup NU author(s): Dr Heather Bigg, Emeritus Professor Drew Rowan


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The collagenases of the matrix metalloproteinase family are key enzymes in mediating irreversible cartilage collagen loss in arthritis. Inhibition of these enzymes is, therefore, an important therapeutic target. New approaches to collagenase inhibition include active site inhibitors designed for specific enzymes, inhibition of cell signalling molecules and transcription factors involved in collagenase gene expression, prevention of zymogen activation and induction of natural inhibitor production. © 2001 Elsevier Science Ltd.

Publication metadata

Author(s): Rowan AD; Bigg HF

Publication type: Article

Publication status: Published

Journal: Current Opinion in Pharmacology

Year: 2001

Volume: 1

Issue: 3

Pages: 314-320

ISSN (print): 1471-4892

ISSN (electronic): 1471-4973

Publisher: Elsevier


DOI: 10.1016/S1471-4892(01)00055-8

PubMed id: 11712757


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