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Lookup NU author(s): Professor David Elliott
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The incidence of testicular neoplasia has increased, and its early detection has become a pressing clinical issue. The strong association between male subfertility and risk of testicular neoplasia is consistent with the existence of common pathogenetic factors. Most forms of testicular germ tumors are believed to stem from a common precursor, intratubular germ cell neoplasia (ITGCN), also known as testicular carcinoma in situ. Identification of ITGCN cells in testicular biopsies, however, is a diagnostic challenge and markers are sorely needed to assist in the accurate identification of the lesion.
Author(s): Lifschitz-Mercer B, Elliott DJ, Schreiber-Bramante L, Leider-Trejo L, Eisenthal A, Maymon BB-S
Publication type: Review
Publication status: Published
Journal: International Journal of Surgical Pathology
ISSN (print): 1066-8969
ISSN (electronic): 1940-2465
PubMed id: 11484508