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Intratubular germ cell neoplasia: Associated infertility and review of the diagnostic modalities

Lookup NU author(s): Professor David Elliott


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The incidence of testicular neoplasia has increased, and its early detection has become a pressing clinical issue. The strong association between male subfertility and risk of testicular neoplasia is consistent with the existence of common pathogenetic factors. Most forms of testicular germ tumors are believed to stem from a common precursor, intratubular germ cell neoplasia (ITGCN), also known as testicular carcinoma in situ. Identification of ITGCN cells in testicular biopsies, however, is a diagnostic challenge and markers are sorely needed to assist in the accurate identification of the lesion.

Publication metadata

Author(s): Lifschitz-Mercer B, Elliott DJ, Schreiber-Bramante L, Leider-Trejo L, Eisenthal A, Maymon BB-S

Publication type: Review

Publication status: Published

Journal: International Journal of Surgical Pathology

Year: 2001

Volume: 9

Issue: 2

Pages: 93-98

ISSN (print): 1066-8969

ISSN (electronic): 1940-2465


DOI: 10.1177/106689690100900202

PubMed id: 11484508