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HLA class II alleles in Chinese patients with hepatocellular carcinoma

Lookup NU author(s): Dr Peter Donaldson


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Background/Aims: Recent reports of an association between human leucocyte antigens (HLA) and persistence of hepatitis B virus infection, and the familial clustering of hepatocellular carcinoma raise the question of genetic susceptibility. Previous studies have been limited to serological phenotyping of HLA B and DR antigens. The aim of this study was to use molecular genotyping to investigate HLA class II as a risk factor for the development of hepatocellular carcinoma in Hong Kong Chinese. Methods: We determined HLA DRB1, DQA1, DQB1 and DPB1 alleles in 123 hepatitis B surface antigen positive patients (84 with hepatocellular carcinoma and 39 without) and 124 matched controls. Results: The alleles DRB1*1501 (36% of HCC patients versus 19% of controls, odds ratio=2.44), DQA1*0102 (42% versus 26%, odds ratio=2.07), and DPB1*0501 (80% versus 63%, odds ratio=2.35) were significantly more common in patients with hepatocellular carcinoma, and DQA1*03 (36% versus 56%, odds ratio=0.53), DQB1*0302 (4% versus 13%, odds ratio=0.25) and DPB1*0201 (14% versus 29%, odds ratio=0.4) were found at significantly lower frequencies. Conclusions: Although none of these associations was significant after correction for multiple testing, this report suggests that further investigations are warranted.

Publication metadata

Author(s): Donaldson PT; Ho S; Williams R; Johnson PJ

Publication type: Article

Publication status: Published

Journal: Liver

Year: 2001

Volume: 21

Issue: 2

Pages: 143-148

Print publication date: 01/01/2001

ISSN (print): 01069543

ISSN (electronic):

DOI: 10.1034/j.1600-0676.2001.021002143.x

PubMed id: 11318984


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