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Lookup NU author(s): Dr Peter Donaldson
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Background/Aims: Recent reports of an association between human leucocyte antigens (HLA) and persistence of hepatitis B virus infection, and the familial clustering of hepatocellular carcinoma raise the question of genetic susceptibility. Previous studies have been limited to serological phenotyping of HLA B and DR antigens. The aim of this study was to use molecular genotyping to investigate HLA class II as a risk factor for the development of hepatocellular carcinoma in Hong Kong Chinese. Methods: We determined HLA DRB1, DQA1, DQB1 and DPB1 alleles in 123 hepatitis B surface antigen positive patients (84 with hepatocellular carcinoma and 39 without) and 124 matched controls. Results: The alleles DRB1*1501 (36% of HCC patients versus 19% of controls, odds ratio=2.44), DQA1*0102 (42% versus 26%, odds ratio=2.07), and DPB1*0501 (80% versus 63%, odds ratio=2.35) were significantly more common in patients with hepatocellular carcinoma, and DQA1*03 (36% versus 56%, odds ratio=0.53), DQB1*0302 (4% versus 13%, odds ratio=0.25) and DPB1*0201 (14% versus 29%, odds ratio=0.4) were found at significantly lower frequencies. Conclusions: Although none of these associations was significant after correction for multiple testing, this report suggests that further investigations are warranted.
Author(s): Donaldson PT; Ho S; Williams R; Johnson PJ
Publication type: Article
Publication status: Published
Journal: Liver
Year: 2001
Volume: 21
Issue: 2
Pages: 143-148
Print publication date: 01/01/2001
ISSN (print): 01069543
ISSN (electronic):
DOI: 10.1034/j.1600-0676.2001.021002143.x
PubMed id: 11318984
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