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Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population

Lookup NU author(s): Emerita Professor Suzanne Cholerton

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Abstract

Catechol-O-methyltransferase (COMT) inactivates neurotransmitters, catechol hormones and drugs such as levodopa and methyldopa. A low activity allele has been demonstrated at codon 108/158 of the soluble and membrane-bound COMT, respectively, whereby a G to A transition results in a valine to methionine substitution. Ethnic and inter-individual differences in red blood cell COMT activity have been observed in the different populations studied so far. Since, no information is available on inter-individual variability of COMT genotype in Turkish population, we genotyped 217 healthy, unrelated Turkish individuals. The allelic frequencies of COMT gene in the Turkish population were found to be the same as has been observed in Caucasians, but different from Orientals.


Publication metadata

Author(s): Kocabas N, Karakaya A, Cholerton S, Sardas S

Publication type: Article

Publication status: Published

Journal: Archives of Toxicology

Year: 2001

Volume: 75

Issue: 7

Pages: 407-409

Print publication date: 01/01/2001

ISSN (print): 0340-5761

ISSN (electronic): 1432-0738

Publisher: Springer

URL: http://dx.doi.org/10.1007/s002040100252

DOI: 10.1007/s002040100252

PubMed id: 11693181


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