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Lookup NU author(s): Professor Robert Lightowlers,
Professor Robert Taylor
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Mitochondrial function is central to a range of cell processes and mitochondrial dysfunction contributes to a number of human diseases. Consequently there is growing interest in delivering large molecules such as nucleic acids, proteins, enzyme mimetics, drugs and probes to mitochondria within cells. The reasons for doing this are to understand how mitochondria function in the cell and to develop therapies for diseases involving mitochondrial damage. Here we review the methods that have been used to target large molecules to mitochondria and discuss some approaches under development. © 2001 Elsevier Science B.V.
Author(s): Lightowlers RN; Taylor RW; Muratovska A; Wilce JA; Murphy MP
Publication type: Review
Publication status: Published
Journal: Advanced Drug Delivery Reviews
ISSN (print): 0169-409X
ISSN (electronic): 1872-8294
PubMed id: 11377811