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Targeting large molecules to mitochondria

Lookup NU author(s): Professor Robert Lightowlers, Professor Robert Taylor


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Mitochondrial function is central to a range of cell processes and mitochondrial dysfunction contributes to a number of human diseases. Consequently there is growing interest in delivering large molecules such as nucleic acids, proteins, enzyme mimetics, drugs and probes to mitochondria within cells. The reasons for doing this are to understand how mitochondria function in the cell and to develop therapies for diseases involving mitochondrial damage. Here we review the methods that have been used to target large molecules to mitochondria and discuss some approaches under development. © 2001 Elsevier Science B.V.

Publication metadata

Author(s): Lightowlers RN; Taylor RW; Muratovska A; Wilce JA; Murphy MP

Publication type: Review

Publication status: Published

Journal: Advanced Drug Delivery Reviews

Year: 2001

Volume: 49

Issue: 1-2

Pages: 189-198

ISSN (print): 0169-409X

ISSN (electronic): 1872-8294


DOI: 10.1016/S0169-409X(01)00134-X

PubMed id: 11377811