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Upper aerodigestive tract cancers in former employees at an iron and steel works

Lookup NU author(s): Denise Howel, Professor Stephen O'Brien, Dr David Chinn, Professor Peter Blain


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Local concern about numbers of laryngeal cancer cases led to an investigation of the incidence of upper aerodigestive tract (UAT) cancer in an industrial cohort. Males (n = 11 470) who had been directly employed at an iron and steel works in northern England at any time between January 1960 and site closure in September 1983 were followed up for UAT cancers until December 1998. The incidence of UAT and laryngeal cancer was compared to the general population of the region via indirect standardization. Fifty-two members of the cohort developed a UAT cancer during 1960-1998. There were no more UAT cancers than expected [standardized incidence ratio = 97, 95% confidence interval (Cl) = 72-127], but slightly more laryngeal cancers than expected (standardized incidence ratio = 118, 95% Cl = 78-171), although this estimate was less precise. The lack of complete work histories meant that relationships between cancer incidence and length of service or job categories could not be explored.

Publication metadata

Author(s): Howel D, O'Brien S, Murphy E, Chinn DJ, McCrone C, French JM, Blain PG

Publication type: Article

Publication status: Published

Journal: Occupational Medicine

Year: 2001

Volume: 51

Issue: 5

Pages: 336-342

Print publication date: 01/01/2001

ISSN (print): 0962-7480

ISSN (electronic): 1471-8405

Publisher: Oxford University Press


DOI: 10.1093/occmed/51.5.336

PubMed id: 11473141


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