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A pharmacokinetic-dynamic explanation of the rapid onset-offset of rapacuronium

Lookup NU author(s): Dr Peter Wright

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Abstract

The rapid onset and offset of rapacuronium can be explained from its pharmacokinetic and pharmacodynamic characteristics. A unique property of rapacuronium is its high value for ke0, indicating a rapid access to the receptor site. The reason for this high ke0 may be related to the low intrinsic potency of rapacuronium, but this is not yet fully clarified.

Publication metadata

Author(s): Proost JH, Wright PMC

Publication type: Article

Publication status: Published

Journal: European Journal of Anaesthesiology, Supplement

Year: 2001

Volume: 18

Issue: S23

Pages: 83-89

ISSN (print): 0952-1941

ISSN (electronic):

Publisher: Greenwich Medical Media

URL: http://dx.doi.org/10.1046/j.0265-0215.2001.15.x

DOI: 10.1046/j.0265-0215.2001.15.x

PubMed id: 11766253

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