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The mitochondrial genome and mitochondrial muscle disorders

Lookup NU author(s): Professor Robert Taylor, Emeritus Professor Doug Turnbull


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Mitochondrial disorders represent a multitude of clinically heterogeneous diseases in which the genetic abnormality can involve either a mitochondrial or nuclear gene. In addition to inherited defects, somatic mitochondrial DNA mutations have been implicated in the pathogenesis of neurodegenerative disease, cancer and the ageing process. The recent emergence of the first mouse models of mitochondrial disease will provide valuable insights into disease mechanisms and aid the development of realistic therapeutic strategies. © 2001 Elsevier Science Ltd.

Publication metadata

Author(s): Taylor RW; Turnbull DM; Schaefer AM

Publication type: Review

Publication status: Published

Journal: Current Opinion in Pharmacology

Year: 2001

Volume: 1

Issue: 3

Pages: 288-293

ISSN (print): 1471-4892

ISSN (electronic): 1471-4973


DOI: 10.1016/S1471-4892(01)00051-0

PubMed id: 11712753