Toggle Main Menu Toggle Search

Open Access padlockePrints

Accelerated telomere shortening in Fanconi anemia fibroblasts - A longitudinal study

Lookup NU author(s): Professor Thomas von Zglinicki


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Fanconi anemia (FA) is a fatal inherited disease displaying chromosomal instability, disturbances in oxygen metabolism and a high burden of intracellular radical oxygen species. Oxygen radicals can damage DNA including telomeric regions. Insufficient repair results in single strand breaks that can induce accelerated telomere shortening. In a longitudinal study we demonstrate that telomeric DNA is continuously lost at a higher rate in FA fibroblasts compared to healthy controls. Furthermore, we show that this loss is caused rather by an increased shortening per cell division in regularly replicating cells than by apoptosis. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

Publication metadata

Author(s): Adelfalk C, Lorenz M, Serra V, von Zglinicki T, Hirsch-Kauffmann M, Schweiger M

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 2001

Volume: 506

Issue: 1

Pages: 22-26

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier BV


DOI: 10.1016/S0014-5793(01)02869-1

PubMed id: 11591364


Altmetrics provided by Altmetric