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Lookup NU author(s): Dr David Cottrell,
Dr Gillian Borthwick,
Emeritus Professor Doug Turnbull
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The chronological accumulation of mitochondrial DNA mutations has been proposed as a potential mechanism in the physiological processes of ageing and age-related disease. We discuss the evidence behind this theory and relate some of the ageing mitochondrial changes to mitochondrial DNA disorders. In particular, we describe the aggregation of cytochrome c oxidase-deficient cells in both skeletal muscle and the CNS in normal ageing as seen in the mitochondrial DNA disorders. These mitochondrial enzyme-deficient cells have been shown to occur in significant quantities in both muscle and CNS in patients with mitochondrial DNA disorders. In both ageing and mtDNA disorder muscle these cytochrome c-deficient fibres contain high levels of a single mutant strain of mitochrondrial DNA. Whether these mutations are a primary or secondary event in the physiology of ageing remains to be determined.
Author(s): Cottrell DA, Blakely EL, Johnson MA, Borthwick GM, Ince PI, Turnbull DM
Editor(s): G Bock, JA Goode
Series Editor(s): Novartis Foundation
Publication type: Book Chapter
Publication status: Published
Book Title: Ageing Vulnerability: Causes and Interventions
Print publication date: 01/01/2001
Series Title: Novartis Foundation Symposium
Publisher: John Wiley & Sons, Ltd.
Place Published: Chichester, UK
PubMed id: 11280028
Library holdings: Search Newcastle University Library for this item