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Transforming growth factor β expression in human placenta and placental bed during early pregnancy

Lookup NU author(s): Dr Helen Simpson, Professor Steve Robson, Dr Judith Bulmer

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Abstract

Normal human pregnancy depends on physiological transformation of spiral arteries. Pre-edampsia and fetal growth restriction are associated with impaired trophoblast invasion and spiral artery transformation. Recent data obtained from studies on placenta suggest that temporal changes in expression of TGF-β3 play a key role in trophoblast invasion and that over-expression of TGF-β3 in pre-eclampsia is responsible for inadequate trophoblast invasion. There are, however, no studies of specific TGF-βs in the placental bed throughout pregnancy although this is where the invasive trophoblast and spiral arteries are located. In this study we have used immunohistochemistry, Western blot analysis, ELISA and RT-PCR to examine the expression of TGF-β1, TGF-β2 and TGF-β3 in placental bed biopsies and placentas from 7-19 weeks' gestation. The results show that TGF-β1, 2 and 3 are expressed in the placenta throughout this time but the striking temporal changes in TGF-β3 expression previously reported were not observed. Extravillous trophoblast within the placental bed expressed TGF-β2 but not TGF-β1 or TGF-β3 while extracellular TGF-β1 and cytoplasmic TGF-β2 were detected in decidua. These data suggest that TGF-β1 and TGF-β2 but not TGF-β3 may play a role in trophoblast invasion. © 2002 Harcourt Publishers Ltd.


Publication metadata

Author(s): Simpson H, Robson SC, Bulmer JN, Barber A, Lyall F

Publication type: Article

Publication status: Published

Journal: Placenta

Year: 2002

Volume: 23

Issue: 1

Pages: 44-58

Print publication date: 01/01/2002

ISSN (print): 0143-4004

ISSN (electronic): 1532-3102

Publisher: Elsevier

URL: http://dx.doi.org/10.1053/plac.2001.0746

DOI: 10.1053/plac.2001.0746

PubMed id: 11869091


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