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Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-ribosylation factors

Lookup NU author(s): Muhamed Hawadle, Dr Trevor Jackson

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Abstract

The ADP-ribosylation factor family of small GTP-binding proteins are implicated in the regulation of vesicular transport and control of cytoskeletal and cell adhesion events. The phosphoinositide 3-kinase, phosphoinositide 4-P 5-kinase and phospholipase D signaling pathways are major regulators of ARF signaling cascades. Two families of ARF regulatory molecules, the cytohesin ARF-Guanine nucleotide Exchange Factors and the centaurin GTPase-Activating Proteins provide key targets for the action of these lipid signals. A critical feature of the regulation of ARF signaling is coordinated recruitment of exchange factors, ARFs and GAPs to appropriate subcellular locations. These complexes drive repetitive cycles of ARF activation and membrane association that underlie the processes of cell movement as well as endosomal uptake and intracellular redistribution of signaling molecules. Cytohesins and centaurins bind specifically to a variety of other signaling proteins and these interactions may provide routes for regulated recruitment to the sites of ARF activation. Through their ability to control endosomal trafficking/recycling of these supramolecular signaling complexes ARF and phospholipid signaling pathways may have consequences that reach as far as the regulation of gene transcription and control of cell fate.


Publication metadata

Author(s): Hawadle MA; Jackson TR; Folarin N; Martin R

Publication type: Article

Publication status: Published

Journal: Biological Research

Year: 2002

Volume: 35

Issue: 2

Pages: 247-265

Print publication date: 01/01/2002

ISSN (print): 0716-9760

ISSN (electronic): 0717-6287

Publisher: Sociedad de Biologia de Chile

PubMed id: 12415743


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