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Lookup NU author(s): Dr Heather Dickinson,
Dr Tibor Nyari,
Professor Louise Parker
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In a retrospective cohort study of all 99976 live births in Cumbria, 1975-1992, we investigated whether higher levels of community infections during the mother's pregnancy and in early life were risk factors for solid tumours (brain/spinal and other tumours), diagnosed 1975-1993 under age 15 years. Logistic regression was used to relate risk to incidente of community infections in three prenatal and two postnatal quarters. There was an increased risk of brain/spinal tumours among children exposed around or soon after birth to higher levels of community infections, in particular measles (OR for trend=2.1, 95%Cl:1.3-3.6, P=0.008) and influenza (OR for exposure=3.3, 95%Cl:1.5-7.4, P=0.005). There was some evidente of an association between exposure to infections around and soon after birth and risk of other tumours, but this may have been a chance finding. The findings are consistent with other recent epidemiological studies suggesting brain tumours may be associated with perinatal exposure to infections. © 2002 Cancer Research UK.
Author(s): Dickinson HO, Nyari TA, Parker L
Publication type: Article
Publication status: Published
Journal: British Journal of Cancer
ISSN (print): 0007-0920
ISSN (electronic): 1532-1827
Publisher: Nature Publishing Group
PubMed id: 12232758
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