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Clinical disorders of extracellular calcium-sensing and the molecular biology of the calcium-sensing receptor

Lookup NU author(s): Professor Simon PearceORCiD


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The calcium-sensing receptor is a G protein-coupled receptor that has a key role in extracellular calcium homeostasis, regulating the secretion of parathyroid hormone and the reabsorption of urinary calcium appropriate to the prevailing calcaemic environment. Molecular abnormalities of the calcium-sensing receptor are responsible for three clinical disorders, familial benign hypocalciuric hypercalcaemia, neonatal severe hyperparathyroidism and autosomal dominant hypocalcaemia with hypercalciuria. In the future, therapeutic compounds that modulate calcium-sensing receptor function may have a role in the medical management of hyperparathyroidism (calcimimetic drugs) and osteoporosis (calcilytic drugs).

Publication metadata

Author(s): Pearce SHS

Publication type: Review

Publication status: Published

Journal: Annals of Medicine

Year: 2002

Volume: 34

Issue: 3

Pages: 201-206

Print publication date: 01/01/2002

ISSN (print): 0785-3890

ISSN (electronic): 1365-2060


DOI: 10.1080/ann.

PubMed id: 12173690