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Lookup NU author(s): Karen Fraser, Frances Davison, Professor John Robinson, Professor Colin Brooks
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NK cells developing in vitro from fetal progenitors in the presence of IL-2 are phenotypically and functionally indistinguishable from mature adult NK cells, with the exception that they generally lack surface expression of any of the Ly49 molecules that have previously been examined. Using two recently developed anti-Ly49 mAb, we show here that most of these NK cells in fact express high levels of at least one previously uncharacterized member of the Ly49 family, most likely Ly49E. Detailed kinetic and clonal analysis revealed that these Ly49 molecules were acquired in a progressive and stochastic manner independently of CD94 and NKG2. CD94 and NKG2 were both expressed early in NK cell development, sometimes in the absence of NK1.1, with CD94 invariably being expressed at two different levels. IL-4 differentially inhibited the expression of CD94 and Ly49 receptors, but had little or no effect on the expression of NKRP1 molecules.
Author(s): Fraser KP, Gays F, Robinson JH, van Beneden K, Leclercq G, Vance RE, Raulet DH, Brooks CG
Publication type: Article
Publication status: Published
Journal: European Journal of Immunology
Year: 2002
Volume: 32
Issue: 3
Pages: 868-878
Print publication date: 01/03/2002
Online publication date: 28/02/2002
Acceptance date: 27/12/2001
ISSN (print): 0014-2980
ISSN (electronic): 1521-4141
Publisher: Wiley - VCH Verlag GmbH & Co. KGaA
URL: http://dx.doi.org/10.1002/1521-4141(200203)32:3<868::AID-IMMU868>3.0.CO;2-A
DOI: 10.1002/1521-4141(200203)32:3<868::AID-IMMU868>3.0.CO;2-A
PubMed id: 11870631
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