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rugose (rg), a drosophila a kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways

Lookup NU author(s): Professor Zofia Chrzanowska-Lightowlers

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Abstract

In the developing Drosophila eye, cell fate determination and pattern formation are directed by cell-cell interactions mediated by signal transduction cascades. Mutations at the rugose locus (rg) result in a rough eye phenotype due to a disorganized retina and aberrant cone cell differentiation, which leads to reduction or complete loss of cone cells. The cone cell phenotype is sensitive to the level of rugose gene function. Molecular analyses show that rugose encodes a Drosophila A kinase anchor protein (DAKAP 550). Genetic interaction studies show that rugose interacts with the components of the EGFR- and Notch-mediated signaling pathways. Our results suggest that rg is required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways.


Publication metadata

Author(s): Shamloula HK, Mbogho MP, Pimentel AC, Chrzanowska-Lightowlers ZMA, Hyatt V, Okano H, Venkatesh TR

Publication type: Article

Publication status: Published

Journal: Genetics

Year: 2002

Volume: 161

Issue: 2

Pages: 693-710

Print publication date: 01/06/2002

ISSN (print): 0016-6731

ISSN (electronic): 1943-2631

Publisher: Genetics Society of America

URL: http://www.genetics.org/cgi/content/full/161/2/693

PubMed id: 12072466


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